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OMFS-0139Soft-tissue lesionsPathologyintermediateTongue

Bluish compressible lesion of the tongue that blanches

19-year-old female

Draft — educational study aid, pending faculty review.

§Chief complaint

Soft bluish lump on the tongue present since childhood

§Medical & dental history

  • 01No coagulopathy; no bleeding disorder
  • 02No trauma or biting history at the site

§Clinical examination

  • 01Soft, compressible bluish-purple lesion 20 mm on the dorsolateral tongue
  • 02Blanches completely on diascopy (positive blanching sign)
  • 03No pulsation, no bruit, no thrill
  • 04Enlarges when the head is placed below the heart

§ figuresFigures (1)

Fig. 1Intermediate magnification micrograph of a capillary hemangioma. H&E stain. Related images Intermed. mag. High mag. Very high mag.

“Capillary hemangioma - intermed mag” · Nephron · CC BY-SA 3.0 · Wikimedia Commons

Verified open-access images only, reproduced for education under their stated licences · no AI-generated or illustrative artwork · Haemangioma figures pending faculty review.

§Differential diagnosis

Venous malformation / haemangiomaCompressible, blanches, positional change
Arteriovenous malformationPulsatile with a bruit and thrill
MucoceleFluctuant but does not blanch
Kaposi sarcomaDoes not blanch; immunosuppression

§Final diagnosis

Venous malformation (low-flow vascular lesion) of the tongue

Blanching on pressure with positional enlargement and no thrill or bruit defines a low-flow venous lesion. A pulsatile, thrilling mass would be a high-flow arteriovenous malformation and would be dangerous to biopsy or excise without embolisation.

§Investigations

  • 01Doppler ultrasound — low-flow venous channels, no arterial feeders
  • 02MRI — high T2 signal, lobulated lesion with phleboliths
  • 03Biopsy avoided as a first-line investigation in a vascular lesion

§Treatment plan

  • 01Observation if asymptomatic
  • 02Sclerotherapy (sodium tetradecyl sulfate or bleomycin) as first-line active treatment
  • 03Surgical excision for residual localised disease after sclerotherapy
  • 04Never biopsy or incise an undiagnosed pulsatile lesion in the oral cavity

§Surgical procedure

  • 01Two sessions of ultrasound-guided sclerotherapy at 8-week intervals
  • 02Residual 6 mm nodule excised with a diode laser

§Follow-up & outcome

  • 01Lesion reduced by more than 80 percent after sclerotherapy
  • 02Speech and tongue mobility normal
  • 03No recurrence at 18 months

§Clinical pearls / learning points

  • 01Diascopy is the free, instant test at the chairside — vascular lesions blanch.
  • 02Never biopsy a suspected high-flow vascular lesion in the mouth; life-threatening haemorrhage can follow.
  • 03Distinguish true infantile haemangioma (proliferates then involutes) from vascular malformations (grow with the child).

§ evidenceReferences & Evidence

Current Classification

WHO Classification of Head and Neck Tumours

5th Edition — Volume 9

WHO Classification of Tumours Editorial Board · 2022

The authoritative international classification of head and neck, odontogenic and salivary gland tumours. Current terminology on this site follows this edition.

Evidence summary

Highest level of evidence linked to this page: WHO / Official Classification.

  • L1 · Classification — 2
  • L6 · Textbook — 3

1 linked source was published from 2024 onwards. Where guidance is limited or contested, rely on the higher-level sources above rather than this summary. Educational use only — not a substitute for clinical judgement.

Content last reviewed

September 2026

Evidence last reviewed

September 2026

Next scheduled review

September 2027

Review status

EVIDENCE REVIEWED

Search latest PubMed evidence

Last literature search: 7 September 2026

Open PubMed

Current Classification

Reference #1L1 · ClassificationWHO / Classification Verified
WHO Classification of Head and Neck Tumours5th Edition — Volume 9

WHO Classification of Tumours Editorial Board. IARC / World Health Organization · 2022

The authoritative international classification of head and neck, odontogenic and salivary gland tumours. Current terminology on this site follows this edition.

DOI: Identifier not availablePMID: Identifier not available
Reference #2L1 · ClassificationWHO / Classification Verified
WHO Classification of Tumours Online — Head and Neck

IARC / WHO. IARC · 2022

Continuously updated online edition of the WHO head and neck tumour classification.

DOI: Identifier not availablePMID: Identifier not available

Histopathology References

Reference #5L6 · TextbookHistopathology References Unverified
Surgical Pathology of the Head and Neck3rd Edition

Barnes L. CRC Press · 2008

Detailed histopathological reference for head and neck diagnostic criteria.

DOI: Identifier not availablePMID: Identifier not available

Textbook References

Reference #3L6 · TextbookTextbooksRecent Verified
Oral and Maxillofacial Pathology5th Edition

Neville BW, Damm DD, Allen CM et al.. Elsevier · 2024

Standard reference textbook of oral and maxillofacial pathology used throughout this atlas.

DOI: Identifier not availablePMID: Identifier not available
Reference #4L6 · TextbookTextbooks Unverified
Shafer's Textbook of Oral Pathology9th Edition

Rajendran R, Sivapathasundharam B. Elsevier · 2020

Undergraduate and postgraduate oral pathology textbook widely used in BDS and FCPS curricula.

DOI: Identifier not availablePMID: Identifier not available

Additional sources cited on this page

  1. ISSVA Classification of Vascular Anomalies (2018).

Browse the full evidence library →

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