Painless mandibular expansion around an unerupted third molar
24-year-old male
§Case presentation
A young adult referred after a routine OPG taken for orthodontic assessment showed a large pericoronal radiolucency around an unerupted 38.
§Chief complaint
Gradual swelling at the back of the lower jaw noticed 6 months ago
§Medical & dental history
- 01Fit and well, no medication
- 02No allergies, non-smoker
- 0338 never erupted
- 04No pain, occasional food packing distal to 37
§Clinical examination
- 01Smooth bony hard expansion of the left mandibular buccal plate from 37 to the angle
- 02Overlying mucosa normal, no discharge or sinus
- 0338 clinically absent; 37 vital and non-tender
- 04Inferior alveolar nerve sensation intact, no trismus
§ figuresFigures (3)
Fig. 1dentigerous jaw cyst in the right mandible around and impacted wisdom tooth
“JawCyst (with arrows)” · JawCyst.jpg: Coronation Dental Specialty Group [1] derivative work: Jbarta · CC BY 3.0 · Wikimedia Commons
Fig. 2dentigerous jaw cyst in the right mandible around and impacted wisdom tooth
“JawCyst (with arrows, cropped)” · JawCyst.jpg: Coronation Dental Specialty Group [1] derivative work: Jbarta and M · CC BY 3.0 · Wikimedia Commons
Verified open-access images only, reproduced for education under their stated licences · no AI-generated or illustrative artwork · Dentigerous Cyst figures pending faculty review.
§Differential diagnosis
§Final diagnosis
Dentigerous cyst associated with impacted 38
A well-corticated unilocular radiolucency attaching at the CEJ of an unerupted tooth, with a pericoronal space greater than 5 mm and no root resorption, is typical. Histology is mandatory because unicystic ameloblastoma and OKC are radiographically indistinguishable.
§Investigations
- 01Pulp sensibility testing of 36 and 37 — both vital
- 02Aspiration — straw-coloured fluid, protein rich, no keratin
- 03Enucleated specimen sent in full for histopathology
§Radiology
- 01OPG — unilocular corticated radiolucency 35 mm attached at the CEJ of 38, crown displaced towards the lower border
- 02IOPA of 37 — intact lamina dura, no root resorption
- 03CBCT — buccal and lingual cortical thinning, inferior alveolar canal displaced inferiorly but cortication preserved
§Treatment plan
- 01Enucleation of the cyst with removal of 38
- 02Preserve 37 — vital and unaffected
- 03Full histopathological examination of the lining
§Surgical procedure
- 01Local anaesthesia with IAN block, buccal envelope flap 36 to retromolar region
- 02Buccal bone removal, tooth sectioned and delivered, lining enucleated intact
- 03Careful protection of the inferior alveolar neurovascular bundle at the cyst floor
- 04Cavity irrigated with saline; primary closure with 3-0 resorbable sutures
§Histopathology report
Cyst lined by thin, non-keratinised stratified squamous epithelium 2-4 cells thick, without rete ridges, on a loose fibromyxoid connective tissue wall containing odontogenic epithelial rests. No dysplasia, no ameloblastic change. Dentigerous cyst.
§Follow-up & outcome
- 011 week — uneventful healing, no paraesthesia
- 026 months — radiographic bone infill, socket consolidating
- 0324 months — near-complete ossification, no recurrence
Outcome: Complete bony healing with preserved inferior alveolar nerve function and no recurrence at 2 years.
§Discussion
- 01Dentigerous cysts are the second most common odontogenic cyst and most often involve mandibular third molars and maxillary canines.
- 02Large lesions in children can be treated by marsupialisation to allow the tooth to erupt and to protect adjacent structures.
- 03Mural ameloblastoma or mucoepidermoid carcinoma arising in the lining is rare but is the reason every specimen is examined histologically.
§Clinical pearls / learning points
- 01A pericoronal radiolucency over 5 mm around an impacted tooth is a cyst until histology says otherwise.
- 02Preserve the inferior alveolar nerve — dissect the cyst floor under direct vision.
- 03Marsupialisation is the conservative option when the associated tooth can still erupt.
§Viva questions
Where does the dentigerous cyst lining attach?
At the cemento-enamel junction of the unerupted tooth, enclosing its crown.
How do you distinguish it from a unicystic ameloblastoma?
Only histologically — ameloblastoma shows a palisaded, hyperchromatic basal layer with reverse polarity and subnuclear vacuolation.
When would you marsupialise?
Large cysts in young patients, when the associated tooth is salvageable, or when enucleation risks the nerve or a pathological fracture.
§MCQs
Q1A dentigerous cyst is derived from which tissue?
Q2The most common site of a dentigerous cyst is:
§ evidenceReferences & Evidence
Current Classification
WHO Classification of Head and Neck Tumours
5th Edition — Volume 9
WHO Classification of Tumours Editorial Board · 2022
The authoritative international classification of head and neck, odontogenic and salivary gland tumours. Current terminology on this site follows this edition.
Evidence summary
Highest level of evidence linked to this page: WHO / Official Classification.
- L1 · Classification — 3
- L4 · Research — 1
- L6 · Textbook — 3
1 linked source was published from 2024 onwards. Where guidance is limited or contested, rely on the higher-level sources above rather than this summary. Educational use only — not a substitute for clinical judgement.
Content last reviewed
September 2026
Evidence last reviewed
September 2026
Next scheduled review
September 2027
Review status
EVIDENCE REVIEWED
Search latest PubMed evidence
Last literature search: 7 September 2026
Current Classification
WHO Classification of Tumours Editorial Board. IARC / World Health Organization · 2022
The authoritative international classification of head and neck, odontogenic and salivary gland tumours. Current terminology on this site follows this edition.
Vered M, Wright JM. Head and neck pathology · 2022 · 16(1):63-75
Summary of odontogenic and maxillofacial bone tumour changes in the 5th edition WHO classification.
IARC / WHO. IARC · 2022
Continuously updated online edition of the WHO head and neck tumour classification.
Radiology References
Dunfee BL, Sakai O, Pistey R et al.. Radiographics : a review publication of the Radiological Society of North America, Inc · 2006 · 26(6):1751-68
Radiologic-pathologic correlation of benign and malignant odontogenic lesions of the jaws.
Histopathology References
Barnes L. CRC Press · 2008
Detailed histopathological reference for head and neck diagnostic criteria.
Textbook References
Neville BW, Damm DD, Allen CM et al.. Elsevier · 2024
Standard reference textbook of oral and maxillofacial pathology used throughout this atlas.
Rajendran R, Sivapathasundharam B. Elsevier · 2020
Undergraduate and postgraduate oral pathology textbook widely used in BDS and FCPS curricula.
Additional sources cited on this page
- WHO Classification of Head and Neck Tumours, 5th edition, 2022.
- Shear M, Speight P. Cysts of the Oral and Maxillofacial Regions, 4th edition.
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