Central Giant Cell Granuloma

aka CGCG

Benign but sometimes locally aggressive intraosseous lesion containing multinucleated giant cells.

§ figuresFigures (2)

Central Giant Cell Granuloma — histopath image: High magnification micrograph of a central giant cell granuloma, abbreviated CGCG. CGCGs are lesions of the mandible or maxilla. The soft tissue counterpart is peripheral giant cell granuloma. CGCG is also known as giant — Fig. 1High magnification micrograph of a central giant cell granuloma, abbreviated CGCG. CGCGs are lesions of the mandible or maxilla. The soft tissue counterpart is peripheral giant cell granuloma. CGCG is also known as giant
“Central giant cell granuloma - high mag” · Nephron · CC BY-SA 3.0 · Wikimedia Commons

Central Giant Cell Granuloma — histopath image: Intermediate magnification micrograph of a central giant cell granuloma, abbreviated CGCG. CGCGs are lesions of the mandible or maxilla. The soft tissue counterpart is peripheral giant cell granuloma. CGCG is also known — Fig. 2Intermediate magnification micrograph of a central giant cell granuloma, abbreviated CGCG. CGCGs are lesions of the mandible or maxilla. The soft tissue counterpart is peripheral giant cell granuloma. CGCG is also known
“Central giant cell granuloma - intermed mag” · Nephron · CC BY-SA 3.0 · Wikimedia Commons

Verified open-access images only, reproduced for education under their stated licences · no AI-generated or illustrative artwork · Central Giant Cell Granuloma figures pending faculty review.

§ overviewOverview

Benign but sometimes locally aggressive intraosseous lesion containing multinucleated giant cells.

§ epidemiologyEpidemiology

Female > male; < 30 years; anterior mandible crossing midline is classical.

§ clinicalClinical Features

01Painless expansile swelling
02May displace teeth or resorb roots

§ differentialDifferential Diagnosis

01Ameloblastoma
02OKC
03Aneurysmal bone cyst
04Brown tumour of hyperparathyroidism (must exclude by serum PTH & calcium)

§ histopathHistopathology

01Multinucleated giant cells in vascular fibrous stroma
02Haemosiderin deposits

§ radiographicRadiographic Features

01Uni- or multilocular radiolucency
02Wispy internal septa; may cross midline

§ treatmentTreatment

01Curettage; intralesional corticosteroids or calcitonin for aggressive lesions
02Resection for recurrent aggressive lesions

§ prognosisPrognosis

Recurrence 15–20% after curettage.

§ pearlsClinical Pearls

01Always check serum calcium & PTH to rule out brown tumour.

Draft — pending faculty review. Educational use only; verify against current guidelines and primary sources before clinical application.