Bone Diseases
Central Giant Cell Granuloma
aka CGCG
Benign but sometimes locally aggressive intraosseous lesion containing multinucleated giant cells.
§ overviewOverview
Benign but sometimes locally aggressive intraosseous lesion containing multinucleated giant cells.
§ epidemiologyEpidemiology
Female > male; < 30 years; anterior mandible crossing midline is classical.
§ clinicalClinical Features
- 01Painless expansile swelling
- 02May displace teeth or resorb roots
§ differentialDifferential Diagnosis
- 01Ameloblastoma
- 02OKC
- 03Aneurysmal bone cyst
- 04Brown tumour of hyperparathyroidism (must exclude by serum PTH & calcium)
§ histopathHistopathology
- 01Multinucleated giant cells in vascular fibrous stroma
- 02Haemosiderin deposits
§ radiographicRadiographic Features
- 01Uni- or multilocular radiolucency
- 02Wispy internal septa; may cross midline
§ treatmentTreatment
- 01Curettage; intralesional corticosteroids or calcitonin for aggressive lesions
- 02Resection for recurrent aggressive lesions
§ prognosisPrognosis
Recurrence 15–20% after curettage.
§ pearlsClinical Pearls
- 01Always check serum calcium & PTH to rule out brown tumour.
Draft — pending faculty review. Educational use only; verify against current guidelines and primary sources before clinical application.