Maxillofacial Infections
Deep Neck Space Infections
aka Fascial Space Infections
Odontogenic infection can spread along fascial planes into potential spaces of the head and neck, threatening the airway, mediastinum and great vessels.
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§ overviewOverview
Infections that spread from the tooth/jaw into the potential spaces bounded by the deep cervical fascia, following predictable anatomical routes.
§ etiologyEtiology
- 01Odontogenic (>60%) — most often mandibular molars
- 02Tonsillar, salivary, traumatic, iatrogenic
§ clinicalClinical Features
- 01Swelling, pain, trismus, dysphagia, drooling
- 02Airway compromise (retro-/parapharyngeal)
- 03Fever, malaise, elevated WCC/CRP
- 04Torticollis (deep spread)
§ investigationsInvestigations
- 01Contrast-enhanced CT head-neck (gold standard)
- 02Aspirate for culture
- 03FBC, CRP, glucose, coagulation
- 04Chest imaging to exclude mediastinitis
§ classificationClassification
- 01Primary spaces adjacent to tooth: buccal, canine, sublingual, submandibular, submental
- 02Secondary/deep spaces: masticator (masseteric, pterygomandibular, temporal), lateral pharyngeal (parapharyngeal), retropharyngeal, prevertebral, danger space (space 4 of Grodinsky-Holyoke)
§ treatmentTreatment
- 01Airway assessment — secure early (awake fibre-optic if compromised)
- 02IV empirical antibiotics: amoxicillin-clavulanate or ampicillin-sulbactam + metronidazole; add clindamycin/vancomycin if MRSA suspected
- 03Surgical: extract source tooth + incision & drainage of involved spaces via appropriate approaches, dependent drainage, corrugated/Penrose drain
- 04ICU support if septic
- 05Reassess and re-image if no improvement in 48–72 h
§ complicationsComplications
- 01Airway obstruction
- 02Descending necrotising mediastinitis (via retropharyngeal/danger space)
- 03Cavernous sinus thrombosis (via canine space and pterygoid plexus)
- 04Lemierre syndrome (internal jugular thrombophlebitis)
- 05Septic shock
§ prognosisPrognosis
Good with early surgical drainage and antibiotics; delayed presentation carries high morbidity/mortality.
§ examKey Examination Points
- 01Trismus + dysphagia = deep space involvement until proven otherwise
- 02Airway is priority
- 03Follow the fascial routes on CT
§ revisionQuick Revision Summary
- 01Odontogenic source · early I&D + antibiotics · watch for mediastinitis
§ vivaBDS Viva Questions
- 01Boundaries of pterygomandibular space?
- 02Danger space?
- 03Cavernous sinus thrombosis route?
§ mcqsMCQs — Assessment (3)
Question 1
Danger space extends to:
Question 2
Trismus most suggests involvement of:
Question 3
First priority:
§ evidenceReferences & Evidence
Current Classification
WHO Classification of Tumours Online — Head and Neck
IARC / WHO · 2022
Continuously updated online edition of the WHO head and neck tumour classification.
Evidence summary
Highest level of evidence linked to this page: WHO / Official Classification.
- L1 · Classification — 1
- L4 · Research — 1
- L6 · Textbook — 3
2 linked sources were published from 2024 onwards. Where guidance is limited or contested, rely on the higher-level sources above rather than this summary. Educational use only — not a substitute for clinical judgement.
Content last reviewed
September 2026
Evidence last reviewed
September 2026
Next scheduled review
September 2027
Review status
EVIDENCE REVIEWED
Search latest PubMed evidence
Last literature search: 7 September 2026
Current Classification
IARC / WHO. IARC · 2022
Continuously updated online edition of the WHO head and neck tumour classification.
Key Research
R MN, R H, M V et al.. Cureus · 2024 · 16(10):e72337
Review of airway assessment and management strategies in deep neck space infection.
Histopathology References
Barnes L. CRC Press · 2008
Detailed histopathological reference for head and neck diagnostic criteria.
Textbook References
Neville BW, Damm DD, Allen CM et al.. Elsevier · 2024
Standard reference textbook of oral and maxillofacial pathology used throughout this atlas.
Rajendran R, Sivapathasundharam B. Elsevier · 2020
Undergraduate and postgraduate oral pathology textbook widely used in BDS and FCPS curricula.
Additional sources cited on this page
- Peterson LJ. Principles of OMFS 3e
Draft — pending faculty review. Educational use only; verify against current guidelines and primary sources before clinical application.